So I had this exact same symptom today.
ST4 1897, iPad 9th Gen, iOS 26.0.1
USB connected to Behringer X32 mixer.
I hadn't used my audio setup for a few hours, then loaded up a song and hit Play - nothing happened. Play button did nothing (i.e. didn't repond, didn't change state).
I closed ST4, restarted it. Play button worked, song played, but no audio.
Turned my Behringer X32 mixer Off and On.
Pressed Play, song played, audio coming through mixer, and all is now back to normal.
Grabbed logs. As I suspected, you can see after the big time gap (Lines 1-2), an error 'waking up' the audio engine:
2025-10-21 10:19:03.562 🔵INFO AudioEngine:327 [b] Pausing audio engine due to app backgrounding
2025-10-21 14:34:41.570 🔵INFO AppState:571 [b] Session Timer reset
2025-10-21 14:34:41.573 🔵INFO AudioEngine:336 [b] Resuming audio engine due to app foregrounding
2025-10-21 14:34:41.574 🔴ERROR AudioEngine:297 [b] Failed to initialize audio engine: Server was dead when activation request was made
it looks like any time I tried to Play a song there would be this fatal error logged:
2025-10-21 14:34:45.160 🔴ERROR TrackPlayer:184 [b] FATAL: Track 0 could not get lastRenderTime
and then eventually
2025-10-21 14:35:44.774 🟡WARN SongPlayer:996 [b] Audio Engine stopped when trying to start playback, starting engine...
2025-10-21 14:35:44.915 🔴ERROR AudioEngine:297 [b] Failed to initialize audio engine: The operation couldn’t be completed. (com.apple.coreaudio.avfaudio error -50.)
2025-10-21 14:35:44.915 🔴ERROR SongPlayer:1000 [b] Audio Engine failed to start!
I'm not convinced this is an ST4 problem because I've had the same occur with ST3. I don't even think this is a ST problem. I suspect it is a problem with iOS and they way it manages audio devices.
I think I'll install Spotify on my iPad so that the next time this occurs, I can test with another audio app and see whether it is just ST or all audio apps that break.
ST Log file here - https://pastebin.com/DpuHESsp